"Mrs. Officer" is the fourth single from Lil Wayne's album Tha Carter III. Its lyrics explore the tension between criminal suspects and police officers by means of the image of sexual tension in the relationship between Lil Wayne and a female police officer; it even goes so far as to reference Rodney King and police brutality, a sexual metaphor which is given almost ambiguous relation. The song features Bobby Valentino and Kidd Kidd, and is produced by Deezle. The song officially debuted on September 9, 2008 It was ranked the No. 25 Hip-Hop song of 2008 by MTV.

The music video was shot in Miami, Florida with Lil Wayne and Gil Green directing it. It is a continuation of the "A Milli" and "Got Money" music videos.

The video was released on October 31, 2008. The last verse of Mrs. Officer, with Kidd Kidd and Bobby Valentino, is cut off and replaced with the first verse from "Comfortable", another track off Tha Carter III which features R&B artist Babyface. Lil Wayne plays the lucky victim, being searched by the female cop (Tammy Torres) an hour after leaving the "A Milli" video shoot. In contrast, Bobby Valentino plays an officer, detaining several women. The "Comfortable" segment of the video is the continuation of "Mrs. Officer" where Lil Wayne and the female officer are living together and for most of the segment argue late in the night on an open street. This segment of the song also contains lines referencing and Beyoncé's "Irreplaceable". Cameos were made Birdman, and Young Money Entertainment artist Mack Maine, and Jae Millz.

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