Mr. & Mrs. Sidney Drew were an American comedy team on stage and screen. The team initially consisted of Sidney Drew (August 28, 1863 – April 9, 1919) and his first wife Gladys Rankin (October 8, 1870 – January 9, 1914). After Gladys died in 1914, Sidney Drew married Lucile McVey (1890–1925), and the two performed as Mr. and Mrs. Sidney Drew.
Sidney Drew or Mr. Sidney Drew as he was usually billed, was an uncle of actors Lionel, Ethel and John Barrymore. Drew's origins have been the subject of speculation. His mother Mrs. Louisa Drew said she adopted him not long after the death of her husband John Drew, Sr. in 1862. Researchers have speculated that Sidney was Mrs. Drew's biological child either from her late husband or from a love affair. It was noticed that she disappeared for some time to the country before returning to Philadelphia with baby Sidney. John Barrymore always said Sidney looked too much like Grandmother Louisa to be anyone else's child.
In his stage career, Sidney Drew was a light-hearted leading man along with his wife, Gladys Rankin, the first Mrs. Sidney Drew. In 1896, the pair introduced legitimate drama to the vaudeville stage. They entered films as a team with the old Kalem Company in 1911, but achieved greater success after their switch to Vitagraph in 1913. Gladys Rankin Drew died later that year from undisclosed causes. Sidney Drew was briefly paired with Clara Kimball Young, with whom Drew starred in the two-reel melodrama satire Goodness Gracious; or, Movies as they Shouldn't Be (1914) directed by Clara's husband James Young.
He remarried to Lucile McVey, born in Sedalia, Missouri, a Vitagraph scriptwriter who briefly went under the name Jane Morrow. Sidney Drew added his new wife to his one-reel comedies, acknowledging McVey as both a writer and co-director. As a comedy team, known as Mr. & Mrs. Sidney Drew, the team perfected the situation comedy style that the team of John Bunny and Flora Finch started. Their style of comedy was usually gentle satire on married life, but also poked fun at the world of show business. Sidney took sole credit as director for two five-reel features at Vitagraph, the groundbreaking cross-gender comedy A Florida Enchantment (1914), in which Edith Storey played the leading female role, and the drama Playing Dead (1915), the Drews' only attempt at a "serious" film.