Mouhamed Saer Sene (born May 12, 1986) is a Senegalese professional basketball player who last played for the Austin Spurs of the NBA Development League. He had a 7 ft 8½ in (2.35 m) wingspan.

Born and raised in Thiès, Senegal, Sene originally went to a private school to become a mechanic, but his father pushed him toward basketball. In 2003, he joined the SEED Academy, a program designed to send Senegalese youths to the United States to play college basketball.

Between 2004 and 2005, Sene attended two Reebok Eurocamps in Treviso, Italy, participated in the Berlin Adidas Camp, played exhibition games against NCAA teams with the Interhoop African All-Stars touring team, and played in Belgium for the Spirou Basket junior squad.

Sene's first professional season came in 2005–06, when he joined VOO Wolves Verviers-Pepinster of the Belgian League. He appeared in 25 games for Verviers-Pepinster, averaging 4.0 points, 5.2 rebounds and 1.0 blocks in 12.3 minutes per game.

On June 28, 2006, Sene was selected by the Seattle SuperSonics with the 10th overall pick in the 2006 NBA draft. He played sparingly for the SuperSonics over the first two months of the 2006–07 season, managing to appear in just 16 games by early January. On January 10, 2007, he was assigned to the Idaho Stampede of the NBA Development League, a stint which lasted until January 26. In his first game back for the SuperSonics on January 28, he scored a season-high 10 points in 12 minutes off the bench against the Los Angeles Clippers. He was later reassigned to Idaho on February 3 and spent the majority of the month of February in the D-League. He finished his rookie season playing in nine games over March and April, totalling 28 games for the SuperSonics in 2006–07.

Sene returned to the SuperSonics for the 2007–08 season but managed just 13 games for the entire season. He spent the majority of his time in the D-League playing for the Idaho Stampede, earning D-League Defensive Player of the Year honors alongside Stephane Lasme at season's end. In 28 games for Idaho in 2007–08, Sene averaged 12.1 points, 8.9 rebounds and 1.7 blocks in 27.5 minutes per game.

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