Monohybrid cross
A monohybrid cross is a mating between two individuals with different alleles at one genetic locus of interest. The character(s) being studied in a monohybrid cross are governed by two or multiple alleles for a single locus. A cross between 2 parents possessing a pair of contrasting characters is known as monohybrid cross. To carry out such a cross, each parent is chosen to be homozygous or true breeding for a given trait (locus). When a cross satisfies the conditions for a monohybrid cross, it is usually detected by a characteristic distribution of second-generation (F2) offspring that is sometimes called the monohybrid ratio.
Generally, the monohybrid cross is used to determine the dominance relationship between two alleles. The cross begins with the parental (P) generation. One parent is homozygous for one allele, and the other parent is homozygous for the other allele. The offspring make up the first filial (F1) generation. Every member of the F1 generation is heterozygous and the phenotype of the F1 generation expresses the dominant trait. Crossing two members of the F1 generation produces the second filial (F2) generation. Probability theory predicts that three quarters of the F2 generation will have the dominant allele's phenotype. And the remaining quarter of the F2s will have the recessive allele's phenotype. This predicted 3:1 phenotypic ratio assumes Mendelian inheritance.
This cross was originally used by biologist Gregor Mendel, who crossed two pea plants to obtain a hybrid variety and discovered the dominance relationships between alleles of several genes.
Gregor Mendel (1822–1884) was an Austrian monk who theorized basic rules of inheritance. From 1858 to 1866, he bred garden peas Pisum sativum in his monastery garden and analyzed the offspring of these matings. The garden pea was chosen as an experimental organism because many varieties were available that bred true for qualitative traits and their pollination could be manipulated. The seven variable characteristics Mendel investigated in pea plants were
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