Molecular Biophysics

Molecular biophysics is a rapidly evolving interdisciplinary area of research that combines concepts in physics, chemistry, engineering, mathematics and biology. It seeks to understand biomolecular systems and explain biological function in terms of molecular structure, structural organization, and dynamic behaviour at various levels of complexity (from single molecules to supramolecular structures, viruses and small living systems). This discipline covers topics such as the measurement of molecular forces, molecular associations, allosteric interactions, Brownian motion, and cable theory. Additional areas of study can be found on Outline of Biophysics. The technical challenges of molecular biophysics are formidable, and the discipline has required development of specialized equipment and procedures capable of imaging and manipulating minute living structures, as well as novel experimental approaches.

In order to be classified as molecular biophysics, the subject studied needs to relate to biophysics and use mathematics at an engineering level, not only to explain the phenomenon, but also to predict future outcomes.

Spectroscopic techniques like FT-NMR, spin label electron spin resonance, laser Raman, FT-infrared, circular dichroism, etc. have been widely used to understand structural dynamics of important bio-molecules and inter-molecular interactions.

Molecular simulations give insight to microscopic structures through various kinds of molecular dynamics software. McCammon and Harvey, authors of Dynamics of proteins and nucleic acids explain the importance of molecular dynamics: “An appreciation of molecular flexibility and dynamics is essential to the design of new molecules with specified activities”.

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