Mihailo Anđelović (Serbian: Михаило Анђеловић, Greek: Μιχαήλ Ἄγγελος) was a Serbian magnate, initially serving the Serbian Despotate with the titles of veliki čelnik and veliki vojvoda, and briefly part of the Serbian three-member regency in 1458. He plotted with the Ottomans but was apprehended, and after brief captivation joined his brother, Ottoman official Mahmud Pasha, as a Timariot.
After the Ottoman conquest of Thessaly in 1394, the ruling Angeloi Philanthropenoi family took refuge in Serbia. Mihailo and his brother (the later Mahmud Pasha) were grandchildren of either Alexios or Manuel. He may have also been related to the noblemen Alessio and Peter Spani through Alexios III Angelos, who was possibly their ancestor. According to Laonikos Chalkokondyles, his brother was captured by the horsemen of Sultan Murad II, while traveling with his mother from Novo Brdo to Smederevo. His brother was abducted as part of the devşirme practice, and became Mahmud, later rising to the highest ranks of the Ottoman Empire, becoming beylerbey (governor-general) of Rumelia in 1451 and Grand Vizier in 1455.