The Mid South Eastern Football League is an Australian rules football competition based in the Limestone Coast region of South Australia. It is an affiliated member of the South Australian National Football League.
The Mid South East Football League formed in 1936 with founding clubs being Glencoe, Kalangadoo, Millicent Centrals (now known as Mount Burr), Millicent Rovers and Tantanoola. Millicent Rovers changed their name to Millicent in 1946, then in 1947 moved to the Mount Gambier & District FL, which later became part of the Western Border Football League.
In 2006 Tantanoola Football Club were premiers, defeating Hatherleigh Football Club.
In 2007 Glencoe Football Club were the premiers beating Tantanoola in the Grand Final. Mt Burr Senior Colts were also Premiers beating Robe in the Final.