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Metronidazole

Metronidazole
Metronidazole.svg
Metronidazole 3D 1w3r.png
Clinical data
Pronunciation /mɛtrəˈndəzl/
Trade names Flagyl, Metro, others
AHFS/Drugs.com Monograph
License data
Pregnancy
category
  • AU: B2
  • US: B (No risk in non-human studies)
Routes of
administration
by mouth, topical, rectal, IV, vaginal
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80% (oral), 60–80% (rectal), 20–25% (vaginal)
Protein binding 20%
Metabolism Hepatic
Biological half-life 8 hours
Excretion Urine (77%), faeces (14%)
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
NIAID ChemDB
PDB ligand
ECHA InfoCard 100.006.489
Chemical and physical data
Formula C6H9N3O3
Molar mass 171.15 g/mol
3D model (Jmol)
Melting point 159 to 163 °C (318 to 325 °F)
  

Metronidazole (MNZ), marketed under the brand name Flagyl among others, is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis. It is the drug of choice for a first episode of mild-to-moderate Clostridium difficile colitis. Metronidazole is available by mouth, as a cream, and intravenously.

Common side effects include nausea, a metallic taste, loss of appetite, and headaches. Occasionally seizures or allergies to the medication may occur. Some state that metronidazole should not be used in early pregnancy while others state doses for trichomoniasis are okay. It should not be used when breastfeeding.

Metronidazole began to be commercially used in 1960 in France. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is available in most areas of the world. The pills are relatively inexpensive, costing between 0.01 and 0.10 USD each. In the United States it is about 26 USD for ten days of treatment.

Metronidazole is primarily used to treat: bacterial vaginosis, pelvic inflammatory disease (along with other antibacterials like ceftriaxone), pseudomembranous colitis, aspiration pneumonia, rosacea (topical), fungating wounds (topical), intra-abdominal infections, lung abscess, periodontitis, amoebiasis, oral infections, giardiasis, trichomoniasis, and infections caused by susceptible anaerobic organisms such as Bacteroides, Fusobacterium, Clostridium, , and Prevotella species. It is also often used to eradicate Helicobacter pylori along with other drugs and to prevent infection in people recovering from surgery.


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