The Metro Suburban Conference (MSC) is an organization of fourteen high schools in northern Illinois, representing seven communities in that part of the state. These high schools are all members of the Illinois High School Association. The conference began competing during the 2006–07 academic year, with four schools from the former Suburban Prairie Conference East Division.
Two new schools (Timothy Christian and Illiana Christian) were added for the 2009–10 academic year, both previously part of the Private School League.Glenbard South High School was added for 2010–11 following the dissolution of the Western Sun Conference.
During the 2013-2014, seven former members of the Suburban Christian Conference decided to move to the MSC, effective during the 2014-2015 academic year. The remaining five high schools moved to either the Chicago Catholic League or the East Suburban Catholic Conference, effectively ended the SCC's run as one of Illinois' premier non-public athletic conferences.