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Methaniazide

Methaniazide
Clinical data
Trade names Erbazid, Neoiscotin, Neo-Iscotin, Nesticide, Neotizide, Neo-Tizide
Identifiers
Synonyms Metaniazide; Neotizide; Isoniazid methanesulfonate; Isoniazid methanosulfonate; Isoniazid mesylate; Isonicotinic acid hydrazide methanesulfonate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C7H9N3O4S
Molar mass 231.226 g/mol
3D model (JSmol)

Methaniazide, brand name Neotizide among others, is an antibiotic which is used in the treatment of tuberculosis. It is the mesylate (methanesulfonate) ester of isoniazid, which is also an antituberculosis drug but has comparatively been far more widely known and used. Isoniazid is a prodrug of isonicotinic acid, and acetylisoniazid, a metabolite of isoniazid, is a metabolic intermediate through which most of the isonicotinic acid is formed. Methaniazide features its mesylate ester at the same position as that of the acetyl ester in acetylisoniazid, and so methaniazide probably acts as a prodrug of isonicotinic acid similarly to isoniazid and acetylisoniazid. Methaniazide is used as the sodium salt.

Neothetazone is an antibiotic combination of methaniazide (neotizide) and thioacetazone which is or was previously used in the treatment of tuberculosis. It has been associated with a case report of gigantomastia. Similarly, there have been a variety of case reports in the literature of gynecomastia associated with isoniazid treatment.




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