Mehmed I Giray, Mukhamad Khan Girai, known as Great (1465–1523) — a khan of the Crimean Khanate in 1515 –1523.
Son of Meñli I Giray, inherited power after his father's death. In 1520 signed a temporary alliance with king of Poland and Grand Duke of Lithuania, Zygmunt I Stary, against Muscovy. In 1521 he took Kazan, where he put his brother, Sahib I Giray (future Khan of Crimea, too) in power. Leading a large Tatar army he defeated Vasili III of Russia near Moscow.
He was married to Nurum Sultan Khatun, daughter of Hasan Bey, of the Manghits. He died in 1523.