Megabyzus (Ancient Greek: Μεγάβυζος, calque of Old Persian Bagabuxša-, meaning "God saved") was a Achaemenid Persian general, son of Zopyrus, satrap of Babylonia. His father was killed when the satrapy rebelled in 482 BC, and Megabyzus led the forces that recaptured the city, after which the statue of the god Marduk was destroyed to prevent future revolts. Megabyzus subsequently took part in the expedition against Greece. Herodotus claims that he refused to act on orders to pillage Delphi, but it is doubtful such orders were ever given.
According to Ctesias, who is not especially reliable but is often our only source, Amytis, wife of Megabyzus and daughter of Xerxes, was accused of adultery shortly afterwards. As such, Megabyzus took part in the conspiracy of Artabanus to assassinate the emperor, but betrayed him before he could kill the new emperor Artaxerxes as well. In a battle, Artabanus' sons were killed and Megabyzus was wounded, but Amytis interceded on his behalf and he was cured.
After this Megabyzus became satrap of Syria. Together with Artabazus, satrap of Phrygia, he had command of the Persian armies sent to put down the revolt of Inarus in Egypt. They arrived in 456 BC, and within two years had put down the revolt, capturing Inarus and various Athenians supporting him(1). They then turned their attention to Cyprus, which was under attack by the Athenians, led by Cimon. Shortly afterwards hostilities between Persia and Athens ceased, called the peace of Callias.