Medial geniculate body

Medial geniculate nucleus
Thalamic nuclei: MNG = Midline nuclear group AN = Anterior nuclear group MD = Medial dorsal nucleus VNG = Ventral nuclear group VA = Ventral anterior nucleus VL = Ventral lateral nucleus VPL = Ventral posterolateral nucleus VPM = Ventral posteromedial nucleus LNG = Lateral nuclear group PUL = Pulvinar MTh = Metathalamus LG = Lateral geniculate nucleus MG = Medial geniculate nucleus
auditory pathway (Medial geniculate body labeled at upper right, second from top)
Details
Part of	Thalamus
System	Auditory system
Artery	Striata
Identifiers
Latin	corpus geniculatum mediale
NeuroNames	hier-338
NeuroLex ID	Medial geniculate body
Dorlands /Elsevier	c_56/12260517
TA	A14.1.08.303 A14.1.08.808
FMA	62211
Anatomical terms of neuroanatomy []

The medial geniculate nucleus (MGN) or medial geniculate body (MGB) is part of the auditory thalamus and represents the thalamic relay between the inferior colliculus (IC) and the auditory cortex (AC). It is made up of a number of sub-nuclei that are distinguished by their neuronal morphology and density, by their afferent and efferent connections, and by the coding properties of their neurons. It is thought that the MGB influences the direction and maintenance of attention.

The MGB has three major divisions; ventral (VMGB), dorsal (DMGB) and medial (MMGB). Whilst the VMGB is specific to auditory information processing, the DMGB and MMGB also receive information from non-auditory pathways.

There are two main cell types in the ventral subnucleus of the medial geniculate body (VMGB):

The VMGB is thought to be primarily responsible for relaying frequency, intensity and binaural information to the cortex. The responses in the VMGB appear to be organized in a tonotopically similar way to those in the IC. The primary difference being that the iso-frequency bands are arranged such that lateral regions are most responsive to low frequencies and medial regions are responsive to high frequencies. Spatiotopic and modulotopic maps (as in the IC) however have not been well supported by mammalian studies. Both monaural (10%) and binaural cells (90%) exist in the MGB. The monaural cells are primarily responsive to sound in the contralateral hemifield. Binaural cells are typically similar to the EE or EI type found in the IC.

There are a large number of cell types present in the dorsal subnucleus of the medial geniculate body (DMGB):

At least two principal cell types have been found, along with two distinct types of interneurons. Several sub-nuclei have been identified based on morphology. No frequency-specific layering has been found in the DMGB.

Many types of responses are present in the DMGB that appear to vary by sub-nuclei. Generally, the responses are broadly tuned, but some cells appear to respond only to complex stimuli. Other cells are multi modal, often responding to somatosensory as well as auditory stimuli.

Cells in the medial subnucleus of the medial geniculate body (MMGB) have large irregular shaped dendritic trees. There is no clear segregation based on the source of these inputs.

The MMGB seems to functionally be responsible for detection of the relative intensity and duration of a sound. It shows a wide range of responses to auditory stimuli. Binaural interactions found in the MMGB include EE, EI, and IE types. Both broadly and narrowly tuned cells have been observed. A type of intensity tuning has also been observed. In this type of cell, the response actually decreases as sound intensity increases above a specific level. Almost all cells in the MMGB appear to respond for the duration of the stimulus, and have very little adaptation. Individual cells still appear to be preferentially tuned to certain frequencies, but they often have more than one and are broadly tuned within these cell frequencies. It is not clear whether there truly is one, none, or many tonotopic organizations maps present in the MMGB. Anaesthetics tend to have large effects on cells within the MMGB, making responses difficult to study. Finally, the behaviour of MMGB cells are complicated by the fact that sensory stimulation from other modalities modifies the responsiveness of many, but not all, cells in the MMGB.