Meadowbrook Run (also known as Meadow Brook Creek) is a tributary of Ithan Creek in Delaware County, Pennsylvania, in the United States. It is approximately 1.9 miles (3.1 km) long and flows through Radnor Township and Haverford Township.
Meadowbrook Run begins just south of Conestoga Road near the community of Bryn Mawr, Pennsylvania. It flows southwest for several tenths of a mile before receiving its first tributary, Finn Run, from the left. Shortly thereafter, it begins to parallel Bryn Mawr Avenue and flows into a small pond where it receives Valley Run from the right. Several hundred feet later, it receives Doom Run from the left. Meadowbrook Run then passes under Bryn Mawr Avenue and meets with a small unnamed tributary. The creek flows into Haverford Township, passes under Interstate 476, and reaches its confluence with Ithan Creek.
Meadowbrook Run joins Ithan Creek 0.30 miles (0.48 km) upriver of its mouth.
The elevation near the mouth of Meadowbrook Run is 200 feet (61 m) above sea level. The elevation of the creek's source is between 340 and 350 feet (100 and 110 m) above sea level.
The watershed of Meadowbrook Run has an area of 2.37 square miles (6.1 km2). The entire creek is in the United States Geological Survey quadrangle of Norristown. The watershed has several different land uses, including urban residential, retail, college campus (Villanova University), and rural or low density residential. Meadowbrook Run periodically floods during large storm events. The stream is not considered to be impaired.