The Meadow River Lumber Company, which operated in Rainelle, West Virginia from 1906 to 1975, was the largest hardwood sawmill in the world. It had three 9 feet (2.7 m) bandsaws under one roof. In 1928, during peak production, its 500 employees produced 31 million board feet (73 thousand cubic meters) of lumber, cutting 3,000 acres (12 km2) of virgin timber a year.
In 1903, the brothers Thomas and John Raine of Ironton, Ohio and later Empire, Pennsylvania joined a lumber firm operating near Evenwood in Randolph County, West Virginia. Later, in 1906, they began purchasing 100,000 acres (400 km2) of land, containing one of the last large stands of virgin hardwood in the United States, mostly on the Meadow River drainage, in western Greenbrier County, West Virginia. Being 20 miles (32 km) to the nearest railroad mainline, they first formed the Sewell Valley Railroad Company to construct a spur line, which eventually evolved into the Meadow River Railroad. This spur was initially used to haul building materials into the wilderness area, and eventually to haul their products out to market. Mill construction began in 1909, and the first board was sawed in September, 1910. Ultimately the mill contained three 9-foot (2.7 m) bandsaws under one roof, making it the largest hardwood sawmill.
The plant and railroad operated several Shay locomotives, one of which was acquired by the Cass Scenic Railroad in 1964, and has since fallen into disrepair.
The plant included a planing mill with the capacity of turning out a million feet (2,360,000 cubic meters) of flooring, ceiling, siding and trim pieces a year. Six large kilns dried lumber for use in the planing mill.
3 miles (4.8 km) of lumber piles, some 40 feet (12 m) high, were stacked on the ten, 1,300 feet (400 m) long lumber docks.