"Me & U" is the debut single by American singer Cassie. It was released on April 25, 2006, as the lead single from her eponymous debut album, Cassie (2006). It was written and produced by Ryan Leslie. The song reached number three on the U.S. Billboard Hot 100 in 2006. It remained in the top forty for nearly five months.

The song's "Bad Boy" remix features Diddy and Yung Joc and the song's "The Inc" remix features Ja Rule and Harry-O. The single has been a successful debut as a top three single in the U.S., a top five single in New Zealand, a top ten hit in the United Kingdom, Ireland, and France, and a top twenty song in Australia. The song is featured on DANCE! Online, a multiplayer online casual video game, Saints Row 2 (2008), and in the PlayStation 4, Microsoft Windows and Xbox One versions of Grand Theft Auto V (2014). It was meant to be featured in Grand Theft Auto IV (2008) and the Xbox 360 and PlayStation 3 versions of Grand Theft Auto V (2013), but was removed for unknown reasons. "Me & U" is also heavily sampled in the 2013 song "Cool" by Le Youth.

The song was considered "a slinky, vintage-sounding track with a hypnotic, snake-charming whistle," and likened to imitating Janet Jackson. The single was certified platinum by the Recording Industry Association of America on December 14, 2006. It was also certified silver by the British Phonographic Industry.

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