McDonnell Genome Institute
| Established | 1993 |
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Field of research
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| Director | Richard K. Wilson |
| Location | St. Louis, Missouri |
| Affiliations | |
| Website | genome.wustl.edu |
McDonnell Genome Institute (The Elizabeth H. and James S. McDonnell III Genome Institute) at Washington University in St. Louis, Missouri, is one of three NIH funded large-scale sequencing centers in the United States. Affiliated with Washington University School of Medicine and the Alvin J. Siteman Cancer Center, the McDonnell Genome Institute is creating, testing and implementing new approaches to the study of genomics with the goal of understanding human health and disease, as well as evolution and the biology of other organisms.
Founded in 1993, the McDonnell Genome Institute, formerly the Genome Sequencing Center and The Genome Institute, began as a key player in the Human Genome Project, ultimately contributing more than 25 percent of the finished sequence. Following completion of the working draft of the human genome in 2000, and the finished human genome sequence in 2003, McDonnell Genome Institute turned its sequencing and analysis skills to determining the genomes of many other organisms in order to provide the first reference sequences for these species. In 2014, civic leaders and longtime philanthropists Elizabeth H. and James S. McDonnell III pledged $25 million to The Genome Institute, which was renamed the Elizabeth H. and James S. McDonnell III Genome Institute at Washington University.
McDonnell Genome Institute employs over 300 full-time faculty and staff from a variety of disciplines. Core staff include:
Richard K Wilson, Ph.D., Director: Dr. Wilson is an expert in molecular genetics and large-scale DNA sequence analysis, and his laboratory at the Washington University School of Medicine is among the world’s leaders in genome analysis. They have sequenced and analyzed billions of bases of DNA from the genomes of bacteria, yeast, roundworms, plants, vertebrates, primates and humans.
Elaine Mardis, Ph.D., Co-Director: Dr. Mardis’ work leading the Technology Development group at the McDonnell Genome Institute has played a pivotal role in the evaluation, optimization and application of new sequencing instrumentation, chemistry and molecular biology toward improved genome sequencing cost, throughput and quality.
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