Mayoko is a town in the Mayoko District, Niari Department, east of the Republic of the Congo.
It is served by a station on the 1,067 mm (3 ft 6 in) Mbinda branch of the Congo-Ocean Railway.
Iron ore deposits are located near the town and the railway. Congo Mining and Exxaro both hold exploration permits nearby.
Coordinates: 02°17′04″S 12°48′30″E / 2.28444°S 12.80833°E