Matthew Francis McGuire (May 30, 1898 – January 24, 1986) was a United States federal judge.
Born in St. John's, Newfoundland and Labrador, McGuire received an A.B. from Holy Cross College in 1921 and an LL.B. from Boston University School of Law in 1926. He was in the United States Navy in 1918. He entered private practice in Boston, Massachusetts in 1926. He was a Special assistant to U.S. attorney general from 1934 to 1939. He was an Assistant to U.S. attorney general from 1940 to 1941.
Judge of the United States District Court for the District of Columbia, McGuire was nominated by President Franklin D. Roosevelt on July 14, 1941, to a seat vacated by Peyton Gordon. He was confirmed by the United States Senate on July 29, 1941, and received his commission on August 1, 1941. He served as chief judge from 1961-1966. He assumed senior status on October 7, 1966. McGuire served in that capacity until his death, in Washington, D.C.