Matilda Sharpe (4 April 1830 – 30 April 1916) was a British teacher, educational reformer and painter who founded Channing House School in Highgate Hill (after Robert Spears' idea) and Highgate Unitarian Chapel, both in north London. She was the daughter of Samuel Sharpe.
Sharpe was a talented painter and several of her portraits are in the collection of the National Portrait Gallery, London.