Throughout history Roman Catholic Mariology has been influenced by a number of saints who have attested to the central role of Mary in God's plan of salvation. The analysis of Early Church Fathers continues to be reflected in modern encyclicals. Irenaeus vigorously defended the title of "Theotokos" or Mother of God. The views of Anthony of Padua, Robert Bellarmine and others supported the doctrine of the Immaculate Conception of the Virgin Mary, which was declared dogma in 1850.
Writings of the saints have contributed to both popular piety and a greater understanding of Mary's role in salvation history.
One of the earliest images of Mary in Christian tradition is that of the "New Eve". Irenaeus of Lyons (circa 140–202) is perhaps the earliest of the Church Fathers to develop a thorough Mariology. In his youth he had met Polycarp other Christians who had been in direct contact with the Apostles. Following Romans 5, his analysis is both scriptural and Christological. presenting Christ as the "New Adam". Irenaeus expands upon the thought of Justin Martyr (100–165), and illustrates the distinction between Eve and Mary in both Adversus haereses (Against Heresies) and in Demonstratio Apostolicae Praedicationis (Proof of the Apostolic Preaching).
According to Irenaeus, Christ, being born out of the Virgin Mary, created a totally new historical situation. This view influences later Ambrose of Milan and Tertullian, who wrote about the virginal conception of the Mother of God. Pope Pius IX made reference to this theme of Irenaeus, in the 1854 apostolic constitution Ineffabilis Deus, which defined the dogma of the Immaculate Conception.
Saint Ambrose of Milan (339–397) Bishop of Milan and Doctor of the Church was one of the most influential ecclesiastical figures of the Fourth Century. A student of Simplician, the virginity of Mary and her role as Mother of God were central to his views on Mary. He portrayed the Mother of God "as devoid off any defect or imperfection, radiant with exception greatness and holiness."