Fizer played high school basketball at Arcadia High School in Arcadia, Louisiana. As a senior, Fizer was selected to play in the McDonald's All-American Game.

Iowa State Cyclones head coach Tim Floyd became aware of Fizer's potential while coaching in Louisiana and interested Fizer in playing collegiate basketball at Iowa State University. Fizer became the first (and only as of 2015-16) McDonald's All-American to play for the Cyclones.

Tim Floyd left Iowa State to coach the Chicago Bulls of the NBA after Fizer's freshman year and was replaced by Larry Eustachy. While playing for both Floyd and Eustachy, Fizer accumulated many Big 12 Conference and national accolades including All-Big 12 honorable mention (freshman), National first-team All-Freshman, first team All-Big 12 (sophomore and junior), Big 12 Player of the Year (junior), Big 12 Tournament Most Outstanding Player (junior), and consensus first-team All-America (junior). He led the Big 12 in scoring his sophomore and junior seasons. Following a Big 12 regular season title, Big 12 tournament title, and NCAA Tournament Elite Eight finish his junior year, Fizer elected to declare for the NBA Draft.

Fizer is ranked fifth on ISU's career scoring list with 1,830 points recorded during his three seasons.

Fizer was selected with the fourth pick of the 2000 NBA Draft by the Chicago Bulls, coached by Tim Floyd, the coach that recruited him to Iowa State. Many analysts suspected that the Bulls had drafted Fizer merely to trade him for another player, since the Bulls already had Elton Brand at the power forward position. However, no such trade ever took place, and Fizer spent the next four years with the Bulls. He never averaged more than 12.3 points per game. Fizer tore his ACL in late January 2003. In 2004, he was selected by the Charlotte Bobcats in the expansion draft. Not making their final roster, he signed as a free agent with the Milwaukee Bucks.

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