Marchiafava–Bignami disease

Marchiafava–Bignami disease
Classification and external resources
Specialty	neurology
ICD-10	G37.1
ICD-9-CM	341.8
DiseasesDB	31494
eMedicine	neuro/204
MeSH	D054319
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Marchiafava–Bignami disease is a progressive neurological disease of alcoholism, characterized by corpus callosum demyelination and necrosis and subsequent atrophy.

It was first described in 1903 by the Italian pathologists Amico Bignami and Ettore Marchiafava in an Italian Chianti drinker. In this patient, Marchiafava and Bignami noticed that the middle two-thirds of the corpus callosum were necrotic.

It is classically associated with chronic alcoholism and sometimes associated nutritional deficiencies.

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