Mar Shimun XXII Paulos (1885 in Qudshanis – May 9, 1920 in Baquba) was a Catholicos Patriarch of the Assyrian Church of the East.
After his brother, Catholicos-Patriarch Mar Shimun XXI Benyamin, was murdered along with 150 of his followers by Simko Shikak (Ismail Agha Shikak), a Kurdish agha, Mar Shimun XXII Paulos was elected on 23 March 1918. He was consecrated in the ancient Church of Mart Maryam (Saint Mary) in Urmia by the metropolitan Mar Eskhaq Khnanisho and the bishops Mar Eliya Abuna of Alqosh, Mar Yosip Khnanisho of Shemsdin (the metropolitan's designated successor), and Mar Zaya Sargis of Jilu.
On 20 August 1918, for fear of persecution from the Ottoman Turks during their campaign of genocide against Armenians, Assyrians, and other Christians of the Ottoman Empire, the newly elected Catholicos-Patriarch fled with about 60,000 of his people from Urmia in Iraq seeking the protection of the British mandate. 15,000 of his followers died on the way. The survivors were in a camp in Baquba, about 50 kilometers north of Baghdad. Becoming very sick, Shimun XXII spent his short patriarchal days at Mor Mottai monastery belonging to the Syriac Orthodox Church of Antioch. He died on 27 April 1920 and buried on 9 May 1920 in the Armenian cemetery in Baghdad.