Manuel María Caballero Province is one of the fifteen provinces of the Bolivian Santa Cruz Department and is situated in the department's western parts. The province name honors deputy Manuel María Caballero from Vallegrande, one of the signatories of the Bolivian constitution (Constitución política) of 5 August 1861.
Manuel María Caballero Province is located between 17° 26' and 18° 15' South and between 64° 07' and 64° 50' West. It extends over 90 km from North to South, and 75 km from West to East.
The province is situated on the western edge of the Bolivian lowlands and borders Cochabamba Department in the West, Vallegrande Province in the South, Florida Province in the East, and Ichilo Province in the Northeast.
The population of Manuel María Caballero Province has increased by circa 35% over the recent two decades:
The province comprises two municipios:
Coordinates: 17°55′S 64°30′W / 17.917°S 64.500°W