Mantua Creek is a tributary of the Delaware River in Mantua Township, Gloucester County, New Jersey in the United States.
Mantua Creek's headwaters are near Glassboro, flowing northwest for 18.6 miles (29.9 kilometers) to the Delaware River at the Port of Paulsboro in Paulsboro across from present-day Philadelphia International Airport.
The name Mantua Creek is derived from the Native American word “Manta”, meaning frog, and was so named because of the remarkable chorus effect produced by abundant frogs in its watershed. Mantua Creek and its two major tributaries, Edwards Run and Chestnut Branch, drain over 50 square miles (130 km2) of Gloucester County.
Early human settlement along Mantua Creek dates back to the Lenni-Lenape Native Americans who exploited its abundance of fish and game and utilized the creeks for transportation. Early European settlers also used the creek for transportation, and constructed saw mills and grist mills on the creek and its streams, encouraging flood plain development for agriculture.
Carpenter's Landing was a 17th-century mercantile settlement located at the head of sloop navigation on Mantua Creek.