Manco Inca Yupanqui (1516–1544) (Manqu Inka Yupanki in Quechua) was the founder and monarch (Sapa Inca) of the independent Neo-Inca State in Vilcabamba, although he was originally a puppet Inca Emperor installed by the Spaniards. He was also known as "Manco II" and "Manco Cápac II" ("Manqu Qhapaq II"). He was one of the sons of Huayna Cápac and a younger brother of Huascar.

Túpac Huallpa was a puppet ruler crowned by the conquistador Francisco Pizarro. After his death, Manco Inca joined Francisco Pizarro and Diego de Almagro in Cajamarca. When Pizarro's force arrived in Cusco, he had the caciques acknowledge Manco as their Inca. Manco Inca then joined Almagro and Hernando de Soto in pursuit of Quizquiz.

When Pizarro left Cuzco with Almagro and Manco Inca, for Jauja in pursuit of Quizquiz, Francisco left his younger brothers Gonzalo Pizarro and Juan Pizarro as regidores, and a ninety-man garrison in the city.

The Pizarro brothers so mistreated Manco Inca that he ultimately tried to escape in 1535. He failed, was captured and imprisoned. Hernando Pizarro released him to recover a golden statue of his father Huayana Capac. Only accompanied by two Spaniards, he easily escaped a second time. Manco then gathered an army of 200,000 Inca warriors and laid siege to Cusco in early 1536, taking advantage of Diego de Almagro's absence.

After ten months (see the siege of Cuzco), Manco retreated to the nearby fortress of Ollantaytambo in 1537. Here Manco successfully defended attacks by the Spaniards in the battle of Ollantaytambo.

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