The Manchester and Lawrence Railroad was a railroad company that was chartered in New Hampshire, United States, by businessmen from Manchester, to build a rail line from that city to the Massachusetts state line.
The Manchester and Lawrence was chartered in 1847 and opened in November 1849. It leased the newly built Methuen Branch from the Boston and Maine Railroad, which opened in August 1849 and ran from South Lawrence through Methuen to the state line where the two lines met.
The B&M tried to lease the M&L, but the company leased itself to the Concord Railroad in 1850. This still helped the B&M as the railroad opened up a second Manchester to Boston route that helped the B&M compete with the combined Nashua and Lowell and Boston and Lowell Railroads. By 1887, the contract was terminated, and the B&M gained control of the line.
In the 20th century, the line was relegated to local freight. Passenger service on the line dropped to one round trip per day until 1953 when regular passenger service ended. Special summer trains ran to Rockingham Park in Salem for the horse races until 1960 when that service stopped.
Despite rapid population growth in Rockingham County in the 1960s and '70s, rail traffic declined. On November 6, 1980, the section of the line from North Salem to Derry was temporarily taken out of service and later abandoned in 1984 by Guilford, having never been reactivated. In 1986 the line from Derry to Londonderry (Manchester Airport) was abandoned. Freight service between the Manchester railyard and the airport continued until 1989, when a severe washout crippled the railbed just north of Goffs Falls Road in South Manchester. Guilford continued to serve the remaining customers from the railyard to South Manchester until 1998. The entire remaining right-of-way from the railyard to Manchester Airport was abandoned in 2000, and the segment that ran through the airport was sold to extend one of the runways.