Mānoa (/ˈmɑː.noʊ.ə/, or informally /mɑːˈnoʊ.ə/) is a valley and a residential neighborhood of Honolulu, Hawaiʻi. The neighborhood is approximately three miles (5 km) east and inland from downtown Honolulu and less than a mile (1600 m) from Ala Moana and Waikīkī at 21°18.87916′N 157°48.4846′W / 21.31465267°N 157.8080767°WCoordinates: 21°18.87916′N 157°48.4846′W / 21.31465267°N 157.8080767°W.