"Makes No Difference" is the first single by Canadian rock band Sum 41. It was released in June 2000 as the lead single from the band's extended play Half Hour of Power. The song is featured on the soundtracks for Bring it On, Out Cold and Van Wilder. A new version of the song was featured on Sum 41's greatest hits compilation, All the Good Shit.

Larry Flick, of Billboard magazine, reviewed the song favorably, saying that it "neatly walks a line between polished modern rock and a clever turn at accessible adult top 40, charged up with grimacing guitars and a pace frantic enough to shake the perm loose from the intended audience's girlfriends."

There are two different music videos of this song.

The first music video is a very large teenage party that Sum 41 is playing at, where a lot of destruction is done to the house as the night goes on, including a car being driven into the house, and features Deryck Whibley with black hair. At one point rapper DMX makes a cameo appearance on an ATV. The other video contains miscellaneous clips of them performing, and features Deryck Whibley with blonde hair.

Cassette:

CD:

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