Mian Noor Muhammad Kalhoro (1698-1755) (Sindhi: ميان نور محمد ڪلهوڙو‎) ruled over Sindh as Subahdar of Mughal Emperor from 1719 till 1736 when he consolidated his power over entire Sindh, subjugating Bakhar Sarkar (Northern Sindh), Sehwan Sarkar (Central Sindh), and Thatta Sarkar (Southern Sindh) under his control and thus establishing a sovereign state, independent of Mughal suzerainty.

In the year 1736, Kalhoro was officially entitled as the Kalhora Nawab of Sindh and was given the title Nawab Khuda-Yar Khan by the Mughal Emperor Muhammad Shah. In 1739, during the invasion of the Mughal Empire by Nader Shah, Mian fled to Umerkot for shelter but was captured by the King of Iran. Mian Noor Mohammad Kalhoro sent a small force to assassinate Nader Shah and turn events in favor of the Mughal Emperor during the notorious Battle of Karnal in 1739, but this plot failed.

In the 4th year of his rule, i.e. 1722, the Daudpotas took certain "aggressive measures". They fought with Mullah Jiyand Abra, who was Miyan Nur Muhammad’s agent in charge of certain villages in Jatoi Parguna of Bakhar Sarkar(Northern Sindh). They further trespassed on the parganahs of Shikarpur, Khanpur and other villages, that formed the jagir of Mir Abdul-Wasia Khan and would not give any explanation to the said Khan. Miyan Nur Muhammad therefore, sent Thariah, one of his confidential men, to the Mughal Emperor Muhammad Shah requesting that under the circumstances the jagir might be conferred on him in his own name, and at the same time marched against the Daudpotas. After some hard fought battles he besieged them in the fort of Shikarpur and compelled them to submit. At last a treaty was agreed upon in which that country was divided into four parts (or shares), two shares being given to the original owner of the jagir, one to the Daudpotas and one being retained by the Miyan Nur Muhammad himself, who after taking some hostages, returned to his capital.

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