Mad as a Hatter

"Mad as a hatter" is a colloquial English phrase used in conversation to suggest (lightheartedly) that a person is suffering from insanity. The etymology of the phrase is uncertain, with explanations both connected and unconnected to the trade of hat-making.

The origin of the saying may derive from:

In a section of the January–June 1829 issue of Blackwood's Edinburgh Magazine, headed Noctes Ambrocianæ. No. XL1V, there is a conversation between a group of fictional characters:

NORTH: Many years – I was Sultan of Bello for a long period, until dethroned by an act of the grossest injustice; but I intend to expose the traitorous conspirators to the indignation of an outraged world.

TICKLER (aside to SHEPHERD.): He's raving.
SHEPHERD (to TICKLER.): Dementit.

Canadian author Thomas Chandler Haliburton used the phrase twice in his 1835 book The clockmaker; or the sayings and doings of Samuel Slick of Slickville: "And with that he turned right round, and sat down to his map and never said another word, lookin' as mad as a hatter the whole blessed time" and "Father he larfed out like any thing; I thought he would never stop – and sister Sall got right up and walked out of the room, as mad as a hatter. Says she, Sam, I do believe you are a born fool, I vow."

...
Wikipedia