Macrocyclic ligand

In chemistry, a macrocyclic ligand is a macrocycle with a ring size of at least nine (including all hetero atoms) and three or more donor sites. Classic examples are crown ethers and porphyrins. Macrocyclic ligands exhibit particularly high affinity for metal ions.

Porphyrins and phthalocyanines have long been recognized as potent ligands in coordination chemistry. In the 1960s the synthesis of macrocylic ligands received much attention, beginning with the synthesis of the "Curtis macrocycles." Similarly, porphyrins, which feature 16-membered central rings, form in the absence of metal templates.

In 1967 a new series of macrocyclic compounds was reported by Pederson, who synthesized a number of cyclic polyethers or “crown” compounds with variety of ring sizes, a number of ether oxygens and substituent groups. Shortly after crown compounds, cryptands, were reported by Lehn and co-workers.

The macrocyclic effect is a term that describes the high affinity of metal cations for macrocyclic ligands, compared to their acyclic analogues. The high affinity of macrocyclic ligands is thought to be a combination of the entropic effect seen in the chelate effect, together with an additional energetic contribution that comes from the preorganized nature of the ligating groups (that is, no additional strains are introduced to the ligand on coordination).

In general, macrocyclic complexes are synthesized by combining macrocyclic ligands and metal ions.

In template reactions, macrocyclic ligands are generated in the presence of metal ions. In the absence of the metal ion, the same organic reactants produce different, often polymeric, products. The term is mainly used in coordination chemistry. The template effects emphasizes the pre-organization provided by the coordination sphere, although the coordination modifies the electronic properties (acidity, electrophilicity, etc.) of ligands. A challenge with templated synthesis of macrocyclic ligands is difficulting in removing the templating metal from the ligand.

The course of the templated cyclization depends on the presence of metal ion, which is provide directional influence, therefore acting as a 'template' for the cyclization reaction. Phthalocyanine was the first macrocycle synthesis by template reaction, bearing strong structural resemblance to natural porphyrin systems. The metal ion may direct the condensation preferentially to cyclic rather than polymeric products (the kinetic template effect) or stabilize the macrocycle once formed (the thermodynamic template effect).

...
Wikipedia