Isaias Guadalupe "Lupe" Aquino (born January 23, 1963 in Chihuahua, Mexico), was a professional boxer (170 cm height) in the super welterweight (154 lb) division. Aquino, known as "Lupe", turned pro in 1981 and won the WBC Light Middleweight Title in 1987 with a decision over Duane Thomas. He lost the title in his first defense via a close decision to Gianfranco Rosi. In 1988 Aquino took on John David Jackson for the inaugural WBO Light Middleweight Title. In the fight, Aquino was put down in 1st and retired after the 7th round. Aquino continued to fight until 1999 but never again challenged for a major title.