Lumefantrine

Lumefantrine

Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a609024
Routes of administration	Oral
ATC code	P01BF01 (WHO) (combination with artemether)
Legal status
Legal status	US: C
Identifiers
IUPAC name 2-(Dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol
CAS Number	82186-77-4 N
PubChem CID	6437380
DrugBank	DB06708 Y
ChemSpider	4941944 Y
UNII	F38R0JR742
KEGG	D03821 Y
ChEBI	CHEBI:156095 Y
ChEMBL	CHEMBL38827 Y
ECHA InfoCard	100.133.797
Chemical and physical data
Formula	C30H32Cl3NO
Molar mass	528.939 g/mol
3D model (Jmol)	Interactive image
SMILES Clc1ccc(cc1)\C=C3\c4c(c2c(cc(Cl)cc23)C(O)CN(CCCC)CCCC)ccc(Cl)c4
InChI InChI=1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- Y Key:DYLGFOYVTXJFJP-MYYYXRDXSA-N Y
NY (what is this?)

Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination. Lumefantrine has a much longer half-life compared to artemether and so is therefore thought to clear any residual parasites that remain after combination treatment.

Lumefantrine, along with pyronaridine and naphtoquine, were synthesized in course of the Project 523 antimalaria drug research initiated in 1967; these compounds are all used in combination antimalaria therapies.