Luis Antonio Meléndez Santana (born August 11, 1949) is a former professional baseball player. He played all or part of eight seasons in Major League Baseball from 1970 until 1977, for the St. Louis Cardinals and San Diego Padres, primarily as an outfielder.

Following his playing career, Meléndez was a minor league manager and coach in the Cardinals and Phillies systems, winning the South Atlantic League championship with the Savannah Cardinals in 1994. He has also managed in the Puerto Rico Baseball League. He was most recently a coach for the Gulf Coast Phillies from 2006 to 2009.