Luigi d'Aragona (1474–1519) (called the Cardinal of Aragón) was an Italian Roman Catholic cardinal. He had a highly successful career in the church, but his memory is affected by the allegation that he ordered the murder of his own sister and two of her children.
Luigi d'Aragona was born in Naples on September 7, 1474, the son of Arrigo d'Aragona and Polissena de Centellas. He was the natural grandson of Ferdinand I of Naples. He held the title of marquis of Gerace. His sister was Giovanna d'Aragona, Duchess of Amlafi.
On June 3, 1492, he married Battistina Cibo Usodimare, granddaughter of Pope Innocent VIII, at the Vatican in the presence of the pope. When Battistina died, Luigi ceded his title of marquis to his brother Carlo and determined to enter the ecclesiastical state.
He received the tonsure on May 6, 1494 from Alessandro Carafa, Archbishop of Naples, in the Archbishop's Palace. He then became a protonotary apostolic.Pope Alexander VI made him a cardinal deacon in pectore in the consistory of May 1494. His creation was published in the consistory of February 19, 1496 and he received the red hat and the deaconry of Santa Maria in Cosmedin.