Louise of Anhalt-Dessau (Dessau, 10 February 1631 – Oława, 25 April 1680), was a German princess of the House of Ascania in the branch of Anhalt-Dessau and by marriage Duchess of Legnica-Brzeg-Wołów-Oława.
She was the fifth child (but third daughter) of John Casimir, Prince of Anhalt-Dessau, by his first wife Agnes, daughter of Maurice, Landgrave of Hesse-Kassel.
Louise married Christian, Duke of Brieg-Oława, on 24 November 1648 in her native city of Dessau. At that time, her husband was only co-ruler with his older brothers George III and Louis IV. Only four years later, in 1652, Louise gave birth to her first child, a daughter called Karolina.
One year after receiving the inheritance of their uncle George Rudolf of Legnica in 1653, George III, Louis IV, and Christian decided to divide up their domains; Christian obtained the small and poor duchies of Wołów and Oława. Louise and her husband settled in Oława, where she gave birth in 1657 a second daughter, Louise, who died on 6 February 1660 at age thirty-two months. Seven months later, on 29 September, the Ducal couple's third child, the long-awaited son and heir, George William, was born. Louise had her fourth and last child in 1664, a second son called Christian Louis, who lived only one month.