"Lose Control" is a hit song by American rapper/songwriter Missy Elliott featuring singer Ciara and rapper Fatman Scoop. It was released as the lead single from Elliott's sixth studio album, The Cookbook. It contains samples from Hot Streak's "Body Work" and Cybotron's "Clear". The song peaked at number-three on the Billboard Hot 100 in the United States, number-two in New Zealand, and in the top thirty in various countries. "Lose Control" received generally favorable reviews and was certified Gold by the Recording Industry Association of America (RIAA).

The song was written by Melissa Elliott, Ciara Harris, Isaac Freeman, Richard Davis and Curtis Hudson and produced by Elliott. The song is an uptempo electronic dance track and contains samples of "Clear" by Cybotron and "Body Work" by Hot Streak, of which Curtis Hudson was a member.

In March 2005, Ciara confirmed she would appear on The Cookbook, singing and rapping on the potential first untitled single at the time. She explained the song's meaning, saying, "It's about music, how music makes you feel and makes you lose control." While recording the song, Elliott stated, "The only person who can pull something off with me [on this track] is Ciara, because it's a record with speed." She went on to say that the toughest part of making the song was convincing Ciara to rap. In the process, Ciara asked Elliott, "Is this gonna sound messed up? My fans are gonna be mad." Along with "On & On", "Lose Control" was released in advance of The Cookbook to determine which song would serve as the lead single.

"Lose Control" received generally favorable reviews from critics. Virgin Media gave the song four out of five stars, calling the song "irresistibly danceable", saying that the sample was "a great spin on the original Cybotron material". In the album review, John Bush of Allmusic said the song was a "nod to the type of old-school party jam that Elliott does better than ever". Brian Hiatt of Rolling Stone called the song one of the "best tracks" on the album. The song was certified Gold by the RIAA.

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