The Lopukhin family was a noble family of the Russian Empire, forming one of the branches of the Sorokoumova-Glebov family. One of its members, Eudoxia Lopukhina, married Peter the Great. When Pyotr Lopukhin's son died childless, the family's princely title passed to Nikolai Petrovich Demidov-Lopukhin. The final Prince Lopukhin-Demidov died in 1995.