Loeffler endocarditis
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Cardiology 
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Loeffler endocarditis is a form of restrictive cardiomyopathy caused by infiltration of the heart by white blood cells known as eosinophils. Restrictive cardiomyopathy is a disease of the heart muscle which results in impaired filling of the heart ventricles, i.e. the large heart chambers which pump blood into the pulmonary or systemic circulation during diastole. Diastole is the part of the cardiac contraction-relaxation cycle in which the heart fills with venous blood after the emptying done during its previous systole (i.e. contraction).
An eosinophil-based specific type of cardiac damage was first described by the Swiss doctor, Wilhelm Loeffler, in 1936. As initially described, the disorder was manifested as a restrictive cardiomyopathy, i.e. a poorly expanding and contracting rigid heart that was infiltrated with eosinophils and showed replacement of cardiac cells by fibrotic connective tissue.
Loeffler endocarditis is now regarded as a manifestation of eosinophilic myocarditis, a disorder that involves the infiltration of heart tissue by blood-born eosinophils that leads to three progressive clinical stages. The first or inflammatory stage involves acute inflammation and subsequent necrosis, i.e. death, of cardiac muscle cells. This stage is dominated by signs and symptoms of the acute coronary syndrome such as angina, heart attack, and congestive heart failure. In the second stage, the endocardium (i.e. interior wall) of the heart forms blood clots which break off and then travel through and block various arteries; this thrombotic stage may dominate the initial presentation in some individuals. The third stage is a fibrotic stage, i.e. Loeffler endocarditis, wherein scarring replaces damaged heart muscle tissue to cause a poorly contracting heart and/or cardiac valve disease. Recent publications commonly refer to Loeffler endocarditis as a historical term for the third stage of eosinophilic myocarditis.
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