"Loco" is the lead Spanish single and overall second single from Enrique Iglesias's album, Sex and Love. The single features American singer Romeo Santos. This is Iglesias' second bachata song after "Cuando Me Enamoro". A banda version of the song was recorded which features Mexican singer Roberto Tapia. Another version of the song featuring Spanish singer India Martínez was released on iTunes on 17 December 2013. At the Latin Grammy Awards of 2014, the song received a nomination for Best Tropical Song.

The music video is directed by Yasha Malekzad, who has also directed the music videos for "Turn the Night Up" and "Dirty Dancer". The video was released on Iglesias' official Vevo channel on YouTube on 26 August 2013. The video has been viewed over 460 million times.

The video starts with Iglesias walking into a bar, while the end of his 1995 song "Por Amarte" is clearly heard. He orders a drink. Beside Iglesias, Santos is sitting and looking tense. Actress Roselyn Sanchez who dances alone onstage under flashing lights, gyrating in a skintight red dress. Tough guy actor Danny Trejo, looks on menacingly. Enrique and Romeo are so down that neither can muster up the energy to approach Sanchez as she sashays past him, though both look on longingly as she walks out the door.

Loco debuted on Billboard Hot 100 chart at number 87 and peaked at number 80, becoming Enrique's highest-charting Spanish song on the chart at the time. It surpassed "Cuando Me Enamoro" which peaked at number 89. The song also debuted in Spain at number 22.

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