Liu Wuzhou (劉武周) (died 622?) was a rebel leader who rose against the rule of the Chinese dynasty Sui Dynasty late in the dynasty's history, and he took imperial style—although it was not completely clear whether the title he took was khan or tianzi. He was initially only able to take control of modern northern Shanxi and parts of central Inner Mongolia, but after Li Yuan established Tang Dynasty at Chang'an as its Emperor Gaozu in 618, he, with support from Eastern Tujue, briefly captured Li Yuan's initial power base of Taiyuan in 619, posing a major threat to Li Yuan's rule. In 620, Li Yuan's son Li Shimin (the future Emperor Taizong) counterattacked, and not only recaptured Taiyuan but further captured Liu's power base Mayi (馬邑, in modern Shuozhou, Shanxi), forcing Liu to flee to Eastern Tujue. When Liu subsequently tried to flee back to Mayi, Eastern Tujue executed him.
Liu Wuzhou's clan was originally from Hejian Commandery (河間, roughly modern Baoding, Hebei). His father Liu Kuang (劉匡) relocated to Mayi (馬邑, in modern Shuozhou, Shanxi). Liu Wuzhou's mother was Liu Kuang's wife Lady Zhao. Liu Wuzhou was known for his strengths and skills at archery, and he often spent time congregating with people with similar dispositions. His older brother Liu Shanbo (劉山伯) was not pleased with this, and often rebuked him, stating, "You are careless with your friendships, and one day you will destroy our clan." Liu Wuzhou therefore left home and went to Sui Dynasty's eastern capital Luoyang, where he served under the general Yang Yichen. During Yang's participation of the campaigns against Goguryeo, Liu Wuzhou, on account of his accomplishments, was made a Xiaowei (校尉) -- an army officer rank just below a general.