"Little Miss Can't Be Wrong" is a song by the rock band Spin Doctors. It was the third track on their 1991 album Pocket Full of Kryptonite and was also its second single.AllMusic describes the song as "incessantly catchy".

The single reached number 2 on Mainstream Rock Tracks and number 17 on the Billboard Hot 100 in the United States; number 23 on the UK Singles Chart; and number 27 in Ireland. Live versions of "What Time Is It?" and "Freeway of the Plains" were included as its B-sides.

Billboard.com credits the song with the eventual commercial success of its parent album: "Pocket Full of Kryptonite had been around for nearly a year when MTV and radio began playing 'Little Miss Can't Be Wrong', but once they started playing it, they couldn't stop."

During a 2011 performance for National Public Radio's World Cafe, lead singer Chris Barron commented that despite popular belief that the song was about an ex-girlfriend, it was actually written about his former stepmother.

...
Wikipedia