List of state highways in Mississippi

Standard route shields
Highway names
Interstates:	Interstate X (I-X)
US Highways:	U.S. Route X (US X)
State:	Mississippi Highway X (MS X)
System links
Mississippi State Highway System Interstate US State Unsigned

State highways in Mississippi are maintained by the Mississippi Department of Transportation. The state numbers its highways in a grid-like pattern, much like the U.S. Route numbering scheme. One and two-digit routes are primary highways.

Odd-numbered routes run north–south and start from MS 1, which runs along the Mississippi River, to MS 25, which runs near the Alabama border. In addition to routes 1 through 25, routes 27 through 41 repeat this pattern over the first several routes, still increasing in number from west to east, and routes 43 and higher generally run in the southern part of the state.

Even-numbered routes run east–west; these start from MS 2, which runs near the Tennessee state line, and continue to MS 26, which runs in the southern part of the state. With the exception of MS 28, the next several even routes are aligned over routes 2 through 26 in a similar fashion.

There are several state highways that are out of place; they do not fit the numbering scheme:

Three-digit highways are organized by their first digit. Routes beginning with a 1 are aborted alignments of U.S. Routes; these include highways 145, 149, 161, 172, 178, 182, 184, and 198. These highways are scattered over their "parent" routes, and have segments beginning and ending in several cities. The exception is MS 178, which covers almost all of the old road (US 78 was relocated onto a new freeway alignment throughout the entire state). U.S. Routes 11, 51, 65, 80, 90, and 278 do not have corresponding state highways, but most of them have at least one aborted alignment.

Highway 245 in Okolona and Crawford is the only three-digit Mississippi Highway to begin with a 2. This is because it is the old alignment of Alternate US 45.

Mississippi highways 301 through 614 are secondary highways that are generally shorter than one- and two-digit highways. These routes are organized so that the 300s run in the northern part of the state, the 400s run in the north-central section, the 500s run in the south-central section, and the 600s run in the most southern section. These routes are numbered like other state highways, with odd routes running north–south and even routes running east–west. The numbering generally increases from the east / north to the west / south within their respective areas.