The list of shipwrecks in 1921 includes all ships sunk, foundered, grounded, or otherwise lost during 1921.
The Wiesbaden-class light cruiser (formerly Kaiserliche Marine) was sunk as a target ship by United States Army Air Service and United States Navy bombers in the Atlantic Ocean off Cape Henry, Virginia.
The Helgoland-class battleship (ex- Kaiserliche Marine) was sunk as a target by United States Army Air Service aircraft in the Atlantic Ocean off Cape Hatteras, North Carolina.