List of most played college football rivalries in NCAA Division I

This is a list of the most played college football rivalries in NCAA Division I. The Lehigh–Lafayette rivalry, known as "The Rivalry," is the most-played in Division I at 152 games. Lehigh and Lafayette are members of of the Football Championship Subdivision (FCS). The most played Football Bowl Subdivision (FBS) rivalry is Minnesota–Wisconsin football rivalry, at 126 games.

Rivalries listed here are not necessarily continuous rivalries, and several of the rivalries listed below were ended (or interrupted) by the 2010–2014 NCAA conference realignment. Nevertheless, conference affiliation is not necessarily an impediment to playing an annual rivalry game, and several match-ups on this list feature teams that have never shared a conference, such as Notre Dame-USC, Miami-Cincinnati, Army-Navy, Clemson-South Carolina, and Georgia-Georgia Tech.

This table lists all rivalries with more than 100 games played. Wins and losses are given respective to the team leading the series.