List of human clusters of differentiation

The following is a list of human clusters of differentiation (or CD) molecules.

* = group; ** = not listed on hcdm

Lilly has developed Olaratumab, (LY3012207) a human IgG1 monoclonal antibody designed to bind to human PDGFRα with high affinity and block PDGF-AA, PDGF-BB, and PDGF-CC ligands from binding to the receptor and is conducting clinical trials in patients with soft-tissue sarcoma.

Various single nucleotide polymorphisms (SNPs) of the OX40L gene have been identified, some associated with systemic lupus erythematosus, but not atherosclerosis.

RANKL affects the immune system and controls bone regeneration. Targeted by mAb drug Denosumab to treat osteoporosis.

Biotech company Mologen is currently (2017) testing a TLR9 agonist, Lefitolimod, for treatment of HIV and various cancers.

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