Y: The Last Man is a comic book series written by Brian K. Vaughan and published by Vertigo Comics, about the sole survivor of the spontaneous, simultaneous death of every male mammal on Earth.
Yorick Brown is the last man on Earth. As such, he often has to travel in disguise to avoid drawing attention from groups like the Daughters of the Amazon. One possible reason he survived the plague is because he owned the monkey Ampersand, and handling Ampersand's feces in cleaning him up gave him Ampersand's resistance to the plague. Another is that a mystical ring protected him from the effects of the plague. Neither explanation is made explicitly clear as to what the real reason for his survival was. He is the son of Jennifer Brown. His sister is Hero Brown.
After the plague hit, Yorick became suicidal due to survivor's guilt; only intervention by Agent 711 restored his will to live. Yorick is also Beth Deville's boyfriend, and maintains a semi-monogamous relationship with her. During their four years apart, he sleeps with one other woman and kisses two others. Since learning that Beth was still alive, he has become obsessed with trying to reunite with her, often leading to arguments with Agent 355 and Dr. Allison Mann over what their priorities should be.
Eventually, he and Beth finally reunite in Paris. However, Beth shocks Yorick by revealing that she had planned to break up with him just before the plague hit, making Yorick realize his entire quest was for nothing. Beth says she is ready to marry Yorick now that he has matured during his journey, but Yorick leaves, just missing his older sister Hero and the other Beth bringing his daughter. He realizes that the love of his life is actually 355 and goes to find her.
Just as they prepare to start a relationship, 355 is shot dead by Alter, leaving Yorick completely devastated. Alter confronts him, but even though she murdered his mother and the woman he loved, he is unable to kill her. He spent years with Beth 2, apparently never loving her and more and more devastated by 355's death. In issue #60, he reflects to all the things he lost during the last 60 years (including Dr. Mann and Ampersand) and manages to escape his padded cell that his daughter committed him to in order to prevent him from killing himself. His final fate is uncertain.