The manga and anime series Omamori Himari features an extensive cast of characters by Milan Matra. The series' storyline focuses on Yuto Amakawa, an orphan who, on the day of his sixteenth birthday, meets Himari, a buxom sword-wielding girl and a cat spirit. Yuto later learns that he is a Demon Slayer and that his family is one of the twelve Demon Slayer families that had slain demons for hundreds of years, and that Himari had sworn an oath set by their ancestors to protect him until his powers awaken. Throughout the series, Yuto, along with his childhood friend Rinko, later encounter other girls who soon take a liking to Yuto: Shizuku, a mizuchi, Lizlet, an artifact spirit, and Kuesu Jinguji, an heiress to the Jinguji Family of Demon Slayers who is revealed to be Yuto's fiancée.
Ayakashi (妖) are the demons and spirits based on Japanese mythology and folklore. They once coexisted with the humans until the Demon Slayers arrived and killed most of them. As a result, the surviving ayakashi bear a deep hatred towards the Demon Slayers. Some ayakashi, like Himari and Shizuku, can assume human forms to blend in with society (though Himari comments that most do not like human cities[ch. 4]), and some ayakashi can cast barriers and spells using their yōki (妖力, lit. "Demon Energy").
Among the ayakashi are three powerful ayakashi known as Japan's Three Evil Demons (日本三大悪妖怪 Nihon Sandai Aku Yōkai), consisting of Shuten-douji, Tama, and Emperor Sutoku, the latter who has yet to appear in the series. They were sealed by humans in ancient times and parts of them were spread throughout Japan in fragments until it was broken by Tama's awakening and Shuten-dōji's revival. It remains unclear if Emperor Sutoku has been freed after the seal was broken. Although the majority of ayakashi in Omamori Himari serve as antagonists, there are some who serve as allies.
Demon Slayers (鬼斬り役 Onikiri-yaku) are humans with supernatural powers and abilities with the duty to slay ayakashi, which has been their primary purpose for hundreds of years. The Demon Slayers were established by the feudal lords who opposed the ayakashi and because of this, most of the surviving ayakashi bear a grudge against them for their near-extinction. The Demon Slayers consist of twelve families, each family having their own unique powers and abilities, such as the Amakawa Family with their Light Ferry ability and the Jinguji Family with their dark magic. Out of the twelve families in feudal times, less than half of the families remain in existence in present times. Each Demon Slayer family is sorted by rank, with the Jinguji Family being at the bottom (#12) and the Tsuchimikado Family at the top (#1).